Session 3 - big (biomedical) data

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    15-Jan-2017

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Slide 1

Big (Biomedical) DataPanel discussion(Chair) Fiona Nielsen, CEO, DNAdigest and RepositiveAdam Auton, Senior Statistical Geneticist, 23andMeMathew Woodwark, Director of Research Bioinformatics, MedImmuneEric Little, VP Data Science, Osthus

Big Biomedical Data chair introductionPistoia Alliance European Conference 2016219 April, 2016Fiona Nielsen, CEO of DNAdigest and Repositive

Pistoia AllianceChair to introduce self and personal connection with subject of the panel (2 min)

19 April 2016

2

Big Biomedical Data introPistoia Alliance European Conference 2016319 April, 2016High throughput technologies biology is moving from the lab to the computer

80+ PB Sequenced every year

Pistoia AllianceFalling cost of sequencing and techological advances

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

3

Big Biomedical Data introPistoia Alliance European Conference 2016419 April, 2016Growing interest and growing databanks

Pistoia Alliance

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 2016519 April, 2016Genomics, Proteomics, metabolomics, all the omics!

Pistoia Alliance

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

5

Big Biomedical Data introPistoia Alliance European Conference 2016619 April, 2016Challenges in all dimensions of big data: Volume, Velocity, Variety, Veracity

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 2016719 April, 2016

Assay TypesDedicated to

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 2016819 April, 2016

Sample # (Log10)Top 5:GEO (1.8M)PMI Cohort Program(1M)Auria Biopankki (1M)EGA (~0.6M)SRA (~0.5M)

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 2016919 April, 2016

AboriginalsAfrican AmericansAfricansAustraliansChineseMalaysIndiansDanishDutchEstonianRussianEuropean AncestryFinnishIcelandicJapaneseKoreanLatin AmericansSaudiSwedish

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 20161019 April, 2016

947560088660266850623250023InternationalInteresting site to look at: http://omicsmaps.com/stats

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

10

Big Biomedical Data introPistoia Alliance European Conference 20161119 April, 2016Challenges in all dimensions of big data: How to collect? How to store? How to analyse?

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 20161219 April, 2016Challenges for international research community: How to work across borders and silos?

Pistoia AllianceHow to advance research without impeding commercial incentives? Potential for pre-competitive collaborations?

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

12

Big Biomedical Data introPistoia Alliance European Conference 20161319 April, 2016Additional challenges for biomedical: Data privacy, data governance, patient consent, medical legislation

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 20161419 April, 2016How will the landscape change when genomics moves to the clinic?

?

Pistoia AllianceIn the light of the increasing costs of drug development, this is an opportunity not to miss!

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

14

Big Biomedical Data introPistoia Alliance European Conference 20161519 April, 2016Is Big Data a promise of Big Findings?

?

Pistoia AllianceIn the light of the increasing costs of drug development, this is an opportunity not to miss!

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 20161619 April, 2016Community-led databanks: patient groups, academia, the general public

Pistoia AllianceDNA.land OpenSNPPersonalGenomesProjectDirect to consumer genetic tests & microbiome

General intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

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Big Biomedical Data introPistoia Alliance European Conference 20161719 April, 2016For our panel discussion: How can Pistoia Alliance members uncover value from Big Biomedical Data?

Pistoia AllianceGeneral intro to the subject assume audience are novices but from technical backgroundWhats hot, whats notMajor recent advancesKey tactical challengesStrategic issues facedRelevance to Pistoia Alliance activity and strategy (if appropriate)

19 April 2016

17

Big (Biomedical) Data panel speakers: Pistoia Alliance European Conference 20161819 April, 2016Adam AutonSenior Statistical Geneticist, 23andMe

Mathew WoodwarkDirector of Research Bioinformatics, MedImmune

Eric LittleVP Data Science, Osthus

Pistoia AllianceTemplate panel self-introductions (1 min each)

19 April 2016

18

Thanks to our panel speakers: Pistoia Alliance European Conference 20161919 April, 2016Adam AutonSenior Statistical Geneticist, 23andMe

Mathew WoodwarkDirector of Research Bioinformatics, MedImmune

Eric LittleVP Data Science, Osthus

Pistoia AllianceTemplate panel self-introductions (1 min each)

19 April 2016

19

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