bio manual 02 7/16 LGS - Welcome to Okaloosa County ... viewb. Organic compounds were on Earth long before organisms, but can also be made inthe laboratory. Organic compounds contain carbon and hydrogen. ... 3. In a condensation reaction, one molecule is stripped of its H+, another is ...

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bio manual 02 7/16 LGS3____________________________________________________________________________________________molecules of LifeChapter Outline26Chapter ThreeMolecules of Life3.1 fear of frying3.2 organic moleculesCarbonThe Stuff of LifeModeling Organic Molecules3.3 molecules of lifefrom structure to functionFunctional GroupsWhat Cells Do to Organic Compounds3.4 CarbohydratesCarbohydrates in Biological Systems Simple SugarsShort-Chain CarbohydratesComplex Carbohydrates3.5 LIPIDSLipids in Biological Systems FatsPhospholipidsWaxesSteroids 3.6 proteins3.7 why is protein structure so important?3.8 Nucleic acidsfear of frying (revisited)SUMMARYSelf-Quizdata analysis ACTIVITIEScritical thinkingChemical Foundations for Cells21Learning Objectives3.1 Examine how trans fats affect human health.3.2 Examine the composition of organic molecules.3.3 Examine the importance of carbon atoms in the molecules of life.3.4 Recognize the importance of organic compounds in biological systems.3.5 Examine how functional groups influence the properties of an organic compound.3.6 Contrast the features of the different types of carbohydrates.3.7 Describe the composition of a lipid molecule.3.8 Examine the different types of naturally occurring lipids using diagrams.3.9 Explain how the structure of a protein influences its function.3.10 Outline the negative consequences of an abnormal protein structure.3.11 Outline the components of a nucleic acid.3.12 Examine the different types of nucleic acids with examples.Key TermsChapter Threeamino acidATPcarbohydratecellulosecondensationdenaturedisaccharidesDNAenzymesfatsfatty acidfunctional groupglycogenhydrocarbonhydrolysislipid bilayerslipids metabolism monomersmonosaccharidesnucleic acidsnucleotidesorganicpeptide bondpeptide polypeptidepolymerspolysaccharidesprionproteinsreactionRNAsaturated fatty acidsstarchsteroidstriglyceridesunsaturated fatty acidswaxMolecules of LifeLecture Outline 3.1 Fear of FryingA.Fats are major constituents of cell membranes and contribute greatly to cell function. Cells require fats, but in appropriate amounts.B.Fatty acids are typical fat molecules with three long carbon fatty acid tails. 1. Small amounts of trans fats are naturally found in red meat and dairy products.2. Hydrogenated fats are manufactured trans fats, which have been widely marketed and are consumed in the American diet.3. Cholesterol levels are increased rapidly by trans fats, particularly hydrogenated fats used as ingredients and in preparation of food. C. Many diseases common to overweight Americans are caused by high consumption of hydrogenated fats. 1. Arteriosclerosis is hardening of the arteries and may be caused by even small amounts of hydrogenated fats.2. Heart attacks are a possible result of atherosclerosis (plaque build-up) due to blockage of cardiac arteries. 3. Diabetes is exacerbated by obesity.3.2Organic MoleculesA.CarbonThe Stuff of Life 1. Oxygen, hydrogen, and carbon are the most abundant elements in living things.a. Carbon and hydrogen are primary constituents of the molecules of lifecomplex carbohydrates, lipids, proteins, and nucleic acidsall organic compounds.b. Organic compounds were on Earth long before organisms, but can also be made inthe laboratory. Organic compounds contain carbon and hydrogen.2.The orientation of the atoms attached to a carbon backbone gives rise to the three-dimensional shape and functions of biological molecules..3.3Molecules of LifeFrom Structure to FunctionA. Simple sugars, fatty acids, amino acids, and nucleotides are monomers, the building blocks of larger molecules.1. Monomers may be joined to form polymers, or polymers may be broken down into monomers for a release of energy.B.What Cells Do to Organic Compounds1. Metabolism is cellular activity. a. Energy is required for cellular reactions.2.Enzymes are a special class of proteins that speed up chemical reactions but remain unchanged.3. In a condensation reaction, one molecule is stripped of its H+, another is stripped of its OH; then the two molecule fragments join to form a new compound, and the H+ and OH form water.4. Hydrolysis is the reverse: one molecule is split by the addition of H+ and OH (from water) to the components. C. Functional Groups 1. Functional groups are atoms or groups of atoms covalently bonded to a carbon backbone. a. Common functional groups in biological molecules are hydroxyl, methyl, carbonyl, carboxyl, amino, phosphate, and sulfhydryl.2. Functional groups convey distinct properties, such as solubility and chemical reactivity, to the entire molecule.3.4 CarbohydratesA. Carbohydrates are organic compounds made of carbon, hydrogen, and oxygen in a 1:2:1 ratio.B. Carbohydrates in Biological Systems 1. Simple Sugarsa.Monosaccharidesone sugar unitare the simplest carbohydrates.b.Ribose and deoxyribose (five-carbon backbones) are building blocks for nucleic acids.c.Glucose (six-carbon backbone) is used by cells as instant energy. 2.Short-Chain Carbohydratesa.An oligosaccharide is a short chain of two or more sugar monomers. b. Oligosaccharides with three or more sugar monomers are attached as short side chains to proteins where they participate in membrane function.c.Disaccharidestwo sugar unitsare the simplest (e.g., sucrose {glucose +fructose} is the most plentiful sugar in nature).3.Complex Carbohydratesa.A polysaccharide is a straight or branched chain of hundreds or thousands of sugar monomers.b.Starch is a plant storage form of energy, arranged as coiled chains, that is easily hydrolyzed to glucose units.c.Cellulose is a fiber-like structural materialtough, insolubleused in plant cell walls.d.Glycogen is a highly-branched chain used by animals to store energy in the muscles and liver.e.Chitin is a specialized polysaccharide with nitrogen attached to the glucose units; it is used as a structural material in arthropod exoskeletons and fungal cell walls.3.5Greasy, OilyMust Be LipidsA. Lipids are nonpolar hydrocarbons that do not dissolve in water.1. A fatty acid is a long, unbranched hydrocarbon with a COOH group at one end. a.Unsaturated fatty acids are liquids (oils) at room temperature because one or more double bonds between the carbons in the tails limit their flexibility. b.Saturated fatty acids have only single CC bonds in their tails and are solids at room temperature. B. Lipids in Biological Systems 1. Fats have one, two, or three fatty acids attached to one glycerol molecule. 2.Triglycerides, such as butter, lard, and oils, are the bodys most abundant and richest source of energy and insulation. a. These lipids have three fatty acid tails attached to a molecule of glycerol.C. Phospholipids1.Phospholipids have a glycerol backbone, two fatty acids, a phosphate group, and a small hydrophilic group.2.They are important components of cell membranes, where the hydrophilic heads face toward the inner and outer surfaces and the hydrophobic tails face inward (bilayer).D.Waxes1.Waxes have long-chain fatty acids attached to long-chain alcohols or carbon rings.2.All are firm and repel water; examples include plant cuticles, bee honeycombs, and animal coverings.E.Steroids 1.Steroids have a backbone of four carbon rings, but no fatty acids.2.Cholesterol, the most common steroid, is found in the cell membranes of animals. a. Cholesterol can be modified to form sex hormones (testosterone and estrogen), bile salts, and vitamin D.3.6ProteinsDiversity in Structure and FunctionA.Proteins function as enzymes, in cell movements, as storage and transport agents, as hormones, as anti-disease agents, and as structural material throughout the body.B. From Structure to Function1. Amino Acids a. Amino acids are small organic molecules with an amine group, an acid group, and one or more R groups.2. Peptide Bonds a. Amino acids are joined in condensation reactions to form peptide bonds. b. Most enzymes are proteins.C. The Structure-Function Relationship 1.Primary structure is defined as the chain (polypeptide) of amino acids each linked together in a definite sequence by peptide bonds between an amino group of one unit and an acid group of another.2.Secondary structure is the helical coil or sheet-like array into which the polypeptide chain is formed by the interaction of hydrogen bonds, which join the side groups of the amino acids.3.Tertiary structure is the result of interactions among R groups that produce a complex three-dimensional shape, such as is found in globular proteins.4.Quaternary structure describes the interaction between two or more polypeptide chains. 5. Some proteins form larger structures such as keratin in fingernails or actin and myosin in muscle cells.3.7Why Is Protein Structure So Important?A. High temperatures or chemicals can cause the three-dimensional shape of proteins to be disrupted in an event known as denaturation.1.Normal protein function is lost upon denaturation, which is usually irreversible (e.g., cooking an egg).B. Prion diseases result from misfolded proteins. 1. Mad cow and Creutzfeldt-Jakob diseases are examples of prion diseases.3.8Nucleic AcidsA.Each nucleotide has a five-carbon sugar (ribose or deoxyribose), a nitrogen-containing base (single- or double-ringed), and a phosphate group.1.ATP (adenosine triphosphate) has three phosphate groups attached to its ribose sugar. 2.ATP is a molecule that provides energy for cellular metabolism.B.In nucleic acids, a covalent bond forms between the sugar of one nucleotide and the phosphate group of the next.1.DNA is double-stranded; genetic messages are encoded in its base sequences: adenine, guanine, cytosine, and thymine.2.RNA is single-stranded; it functions in the assembly of proteins based on the code in DNA.3.9 Fear of Frying (revisited)A. Processed foods often contain trans fatty acids.1. We can break down cis fatty acids, but have more difficulty with trans fatty acids.2. Unprocessed foods do not contain trans fatty acids, so they are a better food choice.Molecules of Life


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