メリケンパークオリエンタルホテル(神戸) takeuchi- ??度でした。 これらの結果から、アジルサルタンは、at1受容体と の親和性が高く、血管へ移行しやすいarbであること

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  • /

    20125

    201210

    Roundtable DiscussionRoundtable Discussion

  • CKD

    2009 JSH2009

    2009

    ARB

    1AT1

    AT1

    AT1

    SpecialLectureARB

    1

    160.0

    21.8p0.0001

    17.5

    159.6

    141.8 142.1

    139.4 138.2

    2way-ANOVA

    0

    20mg 8mg

    40mg12mg

    2 4 6 8 10 12 14 16

    1651601551501451401351301051009590850

    mmHg

    n313n309

    100.3

    12.4p0.0001

    9.8

    100.4

    91.290.6

    89.1 87.9

    62220mg840mg88mg812mg87.3313231.93096

    2

  • AT1

    ARB

    20mg 8 40mg

    8mg812mg

    21.8mmHg17.5mmHg

    1

    24 dipper

    10 20non-dipper 0

    10extreme dipper 20riser

    0

    14

    dipper

    2

    2 2414

    12 14 16 18 20 22 0 2 4 6 8 10 121 21 2

    12 14 16 18 20 22 0 2 4 6 8 10 12

    180

    170

    160

    150

    140

    130

    120

    0

    180

    170

    160

    150

    140

    130

    120

    0

    mmHg

    14

    mmHg

    dippern118non-dippern107risern21extremen27

    dippern118non-dippern107risern21extremen27

    20mg840mg014ABPM2737.331323

    3

  • Discussion

    3

    JSH2009 24

    CKD

    130/80mmHg

    1 CKD

    non-dipper riser

    dipper

    RAS

    extreme-dipper

    RAS

    4

    20125

    1 JSH2009

  • J-MORE I-HAT

    ARB

    1

    1 600

    7

    non-dipper

    dipper 2

    3

    24

    RAS

    RAS

    CREDO-Kyoto Registry

    55

    CKD

    CKD

    2

    CREDO-

    Kyoto cohort-2

    RAS

    5

    2 MACE

    3

    5.37

    n147

    2.35

    n401

    Non-dipper)

    Dipper)

    ABPM-24hr135/80mmHg )

    ABPM-24hr135/80mmHg )

    2.67

    n187

    1.00n807

    6543210

    Ohkubo T et al.: J Hypertens 20: 2183, 20021,542ABPM

  • 12

    RAS

    RAS

    RAS

    4

    RAS RAS

    JCARE-CARD

    52.6%

    JSH2009

    RAS

    A D

    RAS

    A

    D ARB

    EBMCHARM

    JCARE-CARD

    CHARM-

    Preserved

    5

    EXCEED

    5 RAS

    6

    1mg/kg2

    2 1mg/kg 2

    5 4

    100

    13.75

    1 2

    16.55

    13.55

    1.55

    8.17

    11.50

    5.35

    9.63

    2.67

    7.49

    20100

    20

    20125

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